Pulmozyme Dosing & Administration

Pulmozyme is EMA-approved for once- or twice-daily dosing

The recommended dose for most patients is 2.5 mg (corresponding to 2500 U) by inhalation once daily
However, some patients over 21 years of age may benefit from 2.5 mg twice-daily dosing to reduce exacerbation* risk

*Requiring parenteral antibiotics

In intermittent regimes, improvement in Pulmonary function can be lost on cessation of Pulmozyme therapy
Patients should therefore be advised to take their medication every day without a break

Your patients and/or their carers will likely have questions about how to administer Pulmozyme. Each Pulmozyme treatment, requires the following items:

One ampoule of Pulmozyme
- Pulmozyme is supplied in single-use ampoules. It should be stored under refrigeration and kept in the outer carton to protect from light
- One jet nebulizer approved for use with Pulmozyme that can be connected to an air compressor OR nebulizer system*
- Tubing and other components that come with the nebulizer

Remember to communicate these important instructions to patients/caregivers:

Do not dilute or mix Pulmozyme with other drugs in the nebulizer
- Mixing of Pulmozyme with other drugs could lead to adverse structural and/or functional changes in Pulmozyme or the admixed compound
The manufacturers instructions on the use of and maintenance of the nebulizer and compressor should be followed

*A list of recommended nebuliser/compressor systems can be found in section 6.6 of the SmPC

1. Pulmozyme SmPC, Electronic Medicines Compendium, accessed 13/8/18

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